Have just had a double incident with Annatto 160b in Peters Connoisseur Vanilla ice cream. My 6 yr old grandaughter came up in two enormous allergic weals and I had what for me is a classic delayed reaction after 24 hrs. I am salicylate and benzoate intolerant with adverse reactions also to tartrazine and some other colours. I became physically and mentally exhausted with leg trembling which lasted for much of the day. It is a great concern that annatto is now being substituted for artificial colours. It may be of interest to you that we are a family with salicylate intolerance. My brother has Samter’s triad - asthma, nasal polyposis and anaphylaxis to aspirin - Ann